Enlight is a web server that generates figures with epigenetic information and other biological annotations on top of GWAS results.
Identifying causal variants remains a key challenge in post-GWAS (Genome Wide Association Study) era, since many GWAS SNPs fall into non-coding regions, making it especially difficult to associate statistical significance with predicted functionality. Therefore, we created a web-based tool, Enlight, which overlays functional annotation information, such as histone modification states, methylation patterns, transcription factor binding peaks, to GWAS results.
- Visualize the relationship between linkage disequilibrium (LD) and epigenetic information, eQTL, TFBS, and other ChIP-seq data.
- User-friendly web interface
- Text annotation for enrichment analysis or model building.
Enlight is available as a web server from http://enlight.usc.edu/
- Guo Y, Conti D V, Wang K. Enlight: web-based integration of GWAS results with biological annotations Bioinformatics, doi: 10.1093/bioinformatics/btu639, 2014